Precision Temperature Control Unit (TCU) For Biopharma

·Closed-Loop Temperature Control: Uses feedback regulation to automatically correct temperature deviations and maintain stable process temperatures.
·Multi-Mode Regulation: Supports heating, cooling, and heating-cooling switching to cover different process stage requirements.
·Hygienic Design: All-stainless-steel contact parts with dead-leg-free flow channels, supporting clean-in-place procedures.
·Data Traceability: Automatically records operation data, which can be exported for production process compliance management.

·Contact Material: Sanitary-grade stainless steel 316L, suitable for biopharmaceutical production environments.
·Control Method: PLC + touch screen control, supporting custom process curves and parameter settings.
·Temperature Range: Configurable according to process requirements, adapting to low to medium-high temperature conditions.
·Circulation System: Closed circulation pipeline to reduce media loss and lower contamination risk.
·Safety Configuration: Equipped with over-temperature protection, pressure monitoring, and emergency stop devices.
·Cleaning Compatibility: Piping and components designed to meet clean-in-place (CIP) requirements.

·Biopharmaceuticals: Constant temperature control and temperature regulation for bioreactors and fermentation tanks.
·Drug Synthesis: Heating, cooling, and temperature gradient control for reactors and crystallization tanks.
·Vaccine Production: Temperature management for strain cultivation and enzymatic hydrolysis reactions.
·Fine Chemicals: Temperature stability control processes for high-purity synthesis.

·Insufficient Temperature Control Accuracy with Fluctuations Exceeding Process Range
Check the installation position and calibration status of temperature sensors; confirm stable heat transfer medium flow; troubleshoot heat exchanger fouling affecting efficiency.
·Unqualified Heating/Cooling Rate, Unable to Meet Process Time Requirements
Check heat source/cold source supply pressure and temperature; confirm circulation pump operation status; adjust medium flow and valve opening.
·Cross-Contamination Risk During Equipment Operation
Check pipeline dead legs and seal conditions; confirm complete execution of clean-in-place procedures; troubleshoot media backflow or cross-flow.

·Complete medium venting and parameter calibration before startup to confirm normal instrument readings.
·Perform regular clean-in-place procedures to remove residual materials in pipelines and heat exchange components.
·Inspect seals, valves, and pump bodies regularly, and replace them promptly in case of wear or leakage.
·Drain pipeline media and perform sterilization procedures during long-term shutdown to prevent microbial growth.